233 research outputs found
Transitions Induced by the Discreteness of Molecules in a Small Autocatalytic System
Autocatalytic reaction system with a small number of molecules is studied
numerically by stochastic particle simulations. A novel state due to
fluctuation and discreteness in molecular numbers is found, characterized as
extinction of molecule species alternately in the autocatalytic reaction loop.
Phase transition to this state with the change of the system size and flow is
studied, while a single-molecule switch of the molecule distributions is
reported. Relevance of the results to intracellular processes are briefly
discussed.Comment: 5 pages, 4 figure
Knot localization in adsorbing polymer rings
We study by Monte Carlo simulations a model of knotted polymer ring adsorbing
onto an impenetrable, attractive wall. The polymer is described by a
self-avoiding polygon (SAP) on the cubic lattice. We find that the adsorption
transition temperature, the crossover exponent and the metric exponent
, are the same as in the model where the topology of the ring is
unrestricted. By measuring the average length of the knotted portion of the
ring we are able to show that adsorbed knots are localized. This knot
localization transition is triggered by the adsorption transition but is
accompanied by a less sharp variation of the exponent related to the degree of
localization. Indeed, for a whole interval below the adsorption transition, one
can not exclude a contiuous variation with temperature of this exponent. Deep
into the adsorbed phase we are able to verify that knot localization is strong
and well described in terms of the flat knot model.Comment: 27 pages, 10 figures. Submitter to Phys. Rev.
Mapping between dissipative and Hamiltonian systems
Theoretical studies of nonequilibrium systems are complicated by the lack of
a general framework. In this work we first show that a transformation
introduced by Ao recently (J. Phys. A {\bf 37}, L25 (2004)) is related to
previous works of Graham (Z. Physik B {\bf 26}, 397 (1977)) and Eyink {\it et
al.} (J. Stat. Phys. {\bf 83}, 385 (1996)), which can also be viewed as the
generalized application of the Helmholtz theorem in vector calculus. We then
show that systems described by ordinary stochastic differential equations with
white noise can be mapped to thermostated Hamiltonian systems. A steady-state
of a dissipative system corresponds to the equilibrium state of the
corresponding Hamiltonian system. These results provides a solid theoretical
ground for corresponding studies on nonequilibrium dynamics, especially on
nonequilibrium steady state. The mapping permits the application of established
techniques and results for Hamiltonian systems to dissipative non-Hamiltonian
systems, those for thermodynamic equilibrium states to nonequilibrium steady
states. We discuss several implications of the present work.Comment: 18 pages, no figure. final version for publication on J. Phys. A:
Math & Theo
Functional and Biogenetical Heterogeneity of the Inner Membrane of Rat-Liver Mitochondria
Rat liver mitochondria were fragmented by a combined technique of swelling, shrinking, and sonication. Fragments of inner membrane were separated by density gradient centrifugation. They differed in several respects: electronmicroscopic appearance, phospholipid and cytochrome contents, electrophoretic behaviour of proteins and enzymatic activities.
Three types of inner membrane fractions were isolated. The first type is characterized by a high activity of metal chelatase, low activities of succinate-cytochrome c reductase and of glycerolphosphate dehydrogenase, as well as by a high phospholipid content and low contents of cytochromes aa3 and b.
The second type displays maximal activities of glycerolphosphate dehydrogenase and metal chelatase, but contains relatively little cytochromes and has low succinate-cytochrome c reductase activity.
The third type exhibits highest succinate-cytochrome c reductase activity, a high metal chelatase activity and highest cytochrome contents. However, this fraction was low in both glycerolphosphate dehydrogenase activity and phospholipid content. This fraction was also richest in the following enzyme activities: cytochrome oxidase, oligomycin-sensitive ATPase, proline oxidase, 3-hydroxybutyrate dehydrogenase and rotenone-sensitive NADH-cytochrome c reductase.
Amino acid incorporation in vitro and in vivo in the presence of cycloheximide occurs predominantly into inner membrane fractions from the second type.
These data suggest that the inner membrane is composed of differently organized parts, and that polypeptides synthesized by mitochondrial ribosomes are integrated into specific parts of the inner membrane
Live demonstration: Gesture-Based remote control using stereo pair of dynamic vision sensors
This demonstration shows a natural gesture interface for console entertainment devices using as input a stereo pair of dynamic vision sensors. The event-based processing of the sparse sensor output allows fluid interaction at a laptop processor load of less than 3%
Confession Session: Learning from Others Mistakes
Accepted versio
Semi-Dense 3D Reconstruction with a Stereo Event Camera
Event cameras are bio-inspired sensors that offer several advantages, such as
low latency, high-speed and high dynamic range, to tackle challenging scenarios
in computer vision. This paper presents a solution to the problem of 3D
reconstruction from data captured by a stereo event-camera rig moving in a
static scene, such as in the context of stereo Simultaneous Localization and
Mapping. The proposed method consists of the optimization of an energy function
designed to exploit small-baseline spatio-temporal consistency of events
triggered across both stereo image planes. To improve the density of the
reconstruction and to reduce the uncertainty of the estimation, a probabilistic
depth-fusion strategy is also developed. The resulting method has no special
requirements on either the motion of the stereo event-camera rig or on prior
knowledge about the scene. Experiments demonstrate our method can deal with
both texture-rich scenes as well as sparse scenes, outperforming
state-of-the-art stereo methods based on event data image representations.Comment: 19 pages, 8 figures, Video: https://youtu.be/Qrnpj2FD1e
Stochastic Dynamical Structure (SDS) of Nonequilibrium Processes in the Absence of Detailed Balance. IV: Emerging of Stochastic Dynamical Equalities and Steady State Thermodynamics from Darwinian Dynamics
This is the fourth paper, the last one, on solution to the problem of absence
of detailed balance in nonequilibrium processes. It is an approach based on
another known universal dynamics: The evolutionary dynamics first conceived by
Darwin and Wallace, referring to as Darwinian dynamics in the present paper,
has been found to be universally valid in biology; The statistical mechanics
and thermodynamics, while enormously successful in physics, have been in an
awkward situation of wanting a consistent dynamical understanding; Here we
present from a formal point of view an exploration of the connection between
thermodynamics and Darwinian dynamics and a few related topics. We first show
that the stochasticity in Darwinian dynamics implies the existence temperature,
hence the canonical distribution of Boltzmann-Gibbs type. In term of relative
entropy the Second Law of thermodynamics is dynamically demonstrated without
detailed balance condition, and is valid regardless of size of the system. In
particular, the dynamical component responsible for breaking detailed balance
condition does not contribute to the change of the relative entropy. Two types
of stochastic dynamical equalities of current interest are explicitly discussed
in the present approach: One is based on Feynman-Kac formula and another is a
generalization of Einstein relation. Both are directly accessible to
experimental tests. Our demonstration indicates that Darwinian dynamics
represents logically a simple and straightforward starting point for
statistical mechanics and thermodynamics and is complementary to and consistent
with conservative dynamics that dominates the physical sciences. Present
exploration suggests the existence of a unified stochastic dynamical framework
both near and far from equilibrium.Comment: latex, 49 page
Clinical spectrum time course in non-Asian patients positive for anti-MDA5 antibodies
Objectives: To define the clinical spectrum time-course and prognosis of non-Asian patients positive for anti-MDA5 antibodies.
Methods: We conducted a multicentre, international, retrospective cohort study.
Results: 149 anti-MDA5 positive patients (median onset age 53 years, median disease duration 18 months), mainly females (100, 67%), were included. Dermatomyositis (64, 43%) and amyopathic dermatomyositis (47, 31%), were the main diagnosis; 15 patients (10%) were classified as interstitial pneumonia with autoimmune features (IPAF) and 7 (5%) as rheumatoid arthritis. The main clinical findings observed were myositis (84, 56%), interstitial lung disease (ILD) (108, 78%), skin lesions (111, 74%), and arthritis (76, 51%). The onset of these manifestations was not concomitant in 74 cases (50%). Of note, 32 (21.5%) patients were admitted to the intensive care unit for rapidly progressive-ILD, which occurred in median 2 months from lung involvement detection, in the majority of cases (28, 19%) despite previous immunosuppressive treatment. One-third of patients (47, 32% each) was ANA and anti-ENA antibodies negative and a similar percentage was anti-Ro52 kDa antibodies positive. Non-specific interstitial pneumonia (65, 60%), organising pneumonia (23, 21%), and usual interstitial pneumonia-like pattern (14, 13%) were the main ILD patterns observed. Twenty-six patients died (17%), 19 (13%) had a rapidly progressive-ILD.
Conclusions: The clinical spectrum of the anti-MDA5 antibodies-related disease is heterogeneous. Rapidly-progressive ILD deeply impacts the prognosis also in non-Asian patients, occurring early during the disease course. Anti-MDA5 antibody positivity should be considered even when baseline autoimmune screening is negative, anti-Ro52 kDa antibodies are positive, and radiology findings show a NSIP pattern
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